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KMID : 0812020070130020104
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Korean Journal of Neurogastroenterology and Motility
2007 Volume.13 No. 2 p.104 ~ p.110
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The Effect of Visceral Adipose Tissue on the Contractility of Rabbit Gastric Antral Smooth Muscle
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Min Nam-Kee
Park Sung-Ho
Kim Ahn-Sub
Lee Moo-Yeol
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Abstract
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Background/Aims: Some investigators reported that the adipose tissues might affect the contractilityof some vascular smooth muscle. We aimed to demonstrate the effects of adipose tissue in the viscera on the contractile response of rabbit gastric smooth muscle.
Methods: New Zealand White rabbits, around 2.5 kg, were used for the experiments. They were anesthetized with urethane then the antral portion of stomach has been taken and prepared, using force transducer to record itscontractility.
Results: Acetylcholine (ACh) and highly concentrated potassium (K) induced dose-dependentcontractions of the strip. This contractile response was divided into tonic and phasic components and the phasic component was more prominent at high K-induced contraction. Norepinephrine (NE) revealed concentration-dependent relaxation when tonic contraction was induced by 10 mM ACh. Adipose tissues induced weight-dependent relaxations on the both of tonic contractions induced by ACh and/or high K. Adipose tissues did not evoke any remarkable changes on phasic contraction and NE-induced relaxation.
Conclusions: It is likely that the adipose tissue in viscera seem to be affectingthe contractility of gastric smooth muscle via Ca channel inhibitory mechanism. (Kor J Neurogastroenterol Motil 2007;13:104-110)
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KEYWORD
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Adipose tissue, Ca channel, Contractility, Stomach
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